Concentrations of Serotonin in the Rat Striatum
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چکیده
'.'dj we explored _he role of report that dextr0rphan _,L in rat brain. This observ The N-methyl-D-aspartate (NMDA) receptor MDMA-ind ea neurot Male Sprague-Dawle antagonist, dextrorphan, prevents the neurotoxic mic MDMA was synthe effects of 3,4-methylenedioxymethamphetamine t4j.Dextrorphan was ge Groups of rats (n= 6) w ¥, (MDMA) in rats trorphan alone (45 mgj increasing doses of dext '_3I Kevin T. Finnegan, John J. Skratt, lan Irwin and James W. Langston givensubcutaneously,e_ '_ ' phanorsaline (given i t .,! Institute For Medical Research, San Jose, CA 95128 (U.S.A.) and The California Parkinson's Foundation, ' San Jose, CA 95128 (U.S.A.) tion of MDMA. Animal
منابع مشابه
EFFECTS OF CATECHOLAMINES ON DOPAMINE AND SEROTONIN SYNTHESIS IN RAT BRAIN STRIATAL SYNAPTOSOMES: THE ROLE OF PRESYNAPTIC RECEPTORS AND THE SYNAPTOSOMAL REUPTAKE MECHANISM.
The regulation of dopamine and serotonin synthesis in rat brain striatal synaptosomes has been studied using HPLC methods. Noradrenaline was shown to markedly inhibit both the synthesis of dopamine and serotonin. The response of the synaptosomes to the concentrations of noradrenaline appeared to be biphasic, a very effective inhibition occurring at low concentrations (1-5 µm) and a relativ...
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تاریخ انتشار 2001